CATH Domain 3fh7A03

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.390	Neutral Protease; domain 2
	1.10.390.10	Neutral Protease Domain 2

Domain Context

CATH Clusters

Superfamily	Neutral Protease Domain 2
Functional Family	Leukotriene A(4) hydrolase

Enzyme Information

3.3.2.6

Leukotriene-A(4) hydrolase.

based on mapping to UniProt P09960

(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H(2)O = (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate.

-!- A bifunctional zinc metalloprotease that displays both epoxide hydrolase and aminopeptidase activities. -!- It preferentially cleaves tripeptides at an arginyl bond, with dipeptides and tetrapeptides being poorer substrates. -!- It also converts leukotriene A(4) into leukotriene B(4), unlike EC 3.2.2.10 which converts leukotriene A(4) into 5,6-dihydroxy- 7,9,11,14-eicosatetraenoic acid.

UniProtKB Entries (1)

P09960

LKHA4_HUMAN

Homo sapiens

Leukotriene A-4 hydrolase

PDB Structure

PDB	3FH7
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis. Sandanayaka, V., Mamat, B., Mishra, R.K., Winger, J., Krohn, M., Zhou, L.M., Keyvan, M., Enache, L., Sullins, D., Onua, E., Zhang, J., Halldorsdottir, G., Sigthorsdottir, H., Thorlaksdottir, A., Sigthorsson, G., Thorsteinnsdottir, M., Davies, D.R., Stewart, L.J., Zembower, D.E., Andresson, T., Kiselyov, A.S., Singh, J., Gurney, M.E. J.Med.Chem.