CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.60 | Sandwich |
|
2.60.60 | Lipoxygenase-1 |
|
2.60.60.20 | PLAT/LH2 domain |
Domain Context
CATH Clusters
| Superfamily | PLAT/LH2 domain |
| Functional Family |
Enzyme Information
| 1.13.11.40 |
Arachidonate 8-lipoxygenase.
based on mapping to UniProt O16025
Arachidonate + O(2) = (5Z,9E,11Z,14Z)-(8R)-8-hydroperoxyicosa-5,9,11,14- tetraenoate.
-!- An enzyme from the coral Pseudoplexaura porosa.
|
| 4.2.1.92 |
Hydroperoxide dehydratase.
based on mapping to UniProt O16025
(9Z,11E,15Z)-(13S)-hydroperoxyoctadeca-9,11,15-trienoate = (9Z,15Z)- (13S)-12,13-epoxyoctadeca-9,11,15-trienoate + H(2)O.
-!- Acts on a number of unsaturated fatty-acid hydroperoxides, forming the corresponding allene oxides. -!- The product of the above reaction is unstable and is acted upon by EC 5.3.99.6 to form the cyclopentenone derivative (15Z)-12-oxophyto- 10,15-dienoate (OPDA), which is the first cyclic and biologically active metabolite in the jasmonate biosynthesis pathway.
|
UniProtKB Entries (1)
| O16025 |
AOSL_PLEHO
Plexaura homomalla
Allene oxide synthase-lipoxygenase protein
|
PDB Structure
| PDB | 3FG3 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
The 1.85 A structure of an 8R-lipoxygenase suggests a general model for lipoxygenase product specificity.
Biochemistry
|
