CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.10 | Arc Repressor Mutant, subunit A |
|
1.10.10.200 | Integrase, N-terminal zinc-binding domain |
Domain Context
CATH Clusters
| Superfamily | 1.10.10.200 |
| Functional Family |
Enzyme Information
| 3.1.-.- |
Acting on ester bonds.
based on mapping to UniProt P04584
|
| 3.1.13.2 |
Exoribonuclease H.
based on mapping to UniProt P04584
3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid.
-!- This is a secondary reaction to the RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end performed by EC 3.1.26.13.
|
| 2.7.7.7 |
DNA-directed DNA polymerase.
based on mapping to UniProt P04584
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.
|
| 3.4.23.47 |
HIV-2 retropepsin.
based on mapping to UniProt P04584
Endopeptidase for which the P1 residue is preferably hydrophobic.
-!- Responsible for the post-translational processing of the human immunodeficiency virus polyprotein. -!- Belongs to peptidase family A2.
|
| 2.7.7.- |
Nucleotidyltransferases.
based on mapping to UniProt P04584
|
| 3.1.26.13 |
Retroviral ribonuclease H.
based on mapping to UniProt P04584
Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus.
-!- Retroviral reverse transcriptase is a multifunctional enzyme responsible for viral replication. -!- To perform this task the enzyme combines two distinct activities. -!- The polymerase domain (EC 2.7.7.49) occupies the N-terminal two- thirds of the reverse transcriptase whereas the ribonuclease H domain comprises the C-terminal remaining one-third. -!- The RNase H domain of Moloney murine leukemia virus and Human immunodeficiency virus display two metal binding sites.
|
| 2.7.7.49 |
RNA-directed DNA polymerase.
based on mapping to UniProt P04584
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes RNA-template-directed extension of the 3'-end of a DNA strand by one deoxynucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a RNA or DNA primer. -!- DNA can also serve as template. -!- See also EC 2.7.7.7.
|
UniProtKB Entries (2)
| P04584 |
POL_HV2RO
Human immunodeficiency virus type 2 (ISOLATE ROD)
Gag-Pol polyprotein
|
| O75475 |
PSIP1_HUMAN
Homo sapiens
PC4 and SFRS1-interacting protein
|
PDB Structure
| PDB | 3F9K |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
A novel co-crystal structure affords the design of gain-of-function lentiviral integrase mutants in the presence of modified PSIP1/LEDGF/p75
Plos Pathog.
|
