CATH Domain 3f82A01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	Hepatocyte growth factor receptor

Enzyme Information

2.7.10.1

Receptor protein-tyrosine kinase.

based on mapping to UniProt P08581

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P08581

MET_HUMAN

Homo sapiens

Hepatocyte growth factor receptor

PDB Structure

PDB	3F82
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of N-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a Selective and Orally Efficacious Inhibitor of the Met Kinase Superfamily Schroeder, G.M., An, Y., Cai, Z.W., Chen, X.T., Clark, C., Cornelius, L.A., Dai, J., Gullo-Brown, J., Gupta, A., Henley, B., Hunt, J.T., Jeyaseelan, R., Kamath, A., Kim, K., Lippy, J., Lombardo, L.J., Manne, V., Oppenheimer, S., Sack, J.S., Schmidt, R.J., Shen, G., Stefanski, K., Tokarski, J.S., Trainor, G.L., Wautlet, B.S., Wei, D., Williams, D.K., Zhang, Y., Zhang, Y., Fargnoli, J., Borzilleri, R.M. J.Med.Chem.