CATH Domain 3f4bA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.720	NAD(P)-binding Rossmann-like Domain

Domain Context

CATH Clusters

Superfamily	NAD(P)-binding Rossmann-like Domain
Functional Family

Enzyme Information

UniProtKB Entries (1)

Q6TEI5_PLABE

Plasmodium berghei

Enoyl-acyl carrier protein reductase

PDB Structure

PDB	3F4B
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The fatty acid biosynthesis enzyme FabI plays a key role in the development of liver-stage malarial parasites. Yu, M., Kumar, T.R., Nkrumah, L.J., Coppi, A., Retzlaff, S., Li, C.D., Kelly, B.J., Moura, P.A., Lakshmanan, V., Freundlich, J.S., Valderramos, J.C., Vilcheze, C., Siedner, M., Tsai, J.H., Falkard, B., Sidhu, A.B., Purcell, L.A., Gratraud, P., Kremer, L., Waters, A.P., Schiehser, G., Jacobus, D.P., Janse, C.J., Ager, A., Jacobs, W.R., Sacchettini, J.C., Heussler, V., Sinnis, P., Fidock, D.A. Cell Host Microbe