CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.70.370
Functional Family DNA polymerase I

Enzyme Information

2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt P52026
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

P52026
DPO1_GEOSE
Geobacillus stearothermophilus
DNA polymerase I

PDB Structure

PDB 3EZ5
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The Mechanism of the Translocation Step in DNA Replication by DNA Polymerase I: A Computer Simulation Analysis.
Golosov, A.A., Warren, J.J., Beese, L.S., Karplus, M.
Structure