CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.25 | Alpha Horseshoe |
|
1.25.40 | Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat |
|
1.25.40.20 | Ankyrin repeat-containing domain |
Domain Context
CATH Clusters
| Superfamily | Ankyrin repeat-containing domain |
| Functional Family | Palmitoyltransferase |
Enzyme Information
| 2.3.1.225 |
Protein S-acyltransferase.
based on mapping to UniProt Q8IUH5
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.
-!- The enzyme catalyzes the posttranslational protein palmitoylation that plays a role in protein-membrane interactions, protein trafficking, and enzyme activity. -!- Palmitoylation increases the hydrophobicity of proteins or protein domains and contributes to their membrane association.
|
UniProtKB Entries (1)
| Q8IUH5 |
ZDH17_HUMAN
Homo sapiens
Palmitoyltransferase ZDHHC17
|
PDB Structure
| PDB | 3EU9 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
The ankyrin repeat domain of Huntingtin interacting protein 14 contains a surface aromatic cage, a potential site for methyl-lysine binding.
Proteins
|
