CATH Classification

Domain Context

CATH Clusters

Superfamily ATP-grasp fold, B domain
Functional Family N5-carboxyaminoimidazole ribonucleotide synthase

Enzyme Information

6.3.4.18
5-(carboxyamino)imidazole ribonucleotide synthase.
based on mapping to UniProt P09029
ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO(3)(-) = ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole.
-!- In Escherichia coli, this enzyme, along with EC 5.4.99.18, is required to carry out the single reaction catalyzed by EC 4.1.1.21 in vertebrates. -!- Carboxyphosphate is the putative acyl phosphate intermediate. -!- Involved in the late stages of purine biosynthesis.

UniProtKB Entries (1)

P09029
PURK_ECOLI
Escherichia coli K-12
N5-carboxyaminoimidazole ribonucleotide synthase

PDB Structure

PDB 3ETJ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural analysis of the active site geometry of N(5)-Carboxyaminoimidazole ribonucleotide synthetase from Escherichia coli.
Thoden, J.B., Holden, H.M., Firestine, S.M.
Biochemistry