CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.30 | 2-Layer Sandwich | |
3.30.470 | D-amino Acid Aminotransferase; Chain A, domain 1 | |
3.30.470.20 | ATP-grasp fold, B domain |
Domain Context
CATH Clusters
Superfamily | ATP-grasp fold, B domain |
Functional Family | N5-carboxyaminoimidazole ribonucleotide synthase |
Enzyme Information
6.3.4.18 |
5-(carboxyamino)imidazole ribonucleotide synthase.
based on mapping to UniProt P09029
ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO(3)(-) = ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole.
-!- In Escherichia coli, this enzyme, along with EC 5.4.99.18, is required to carry out the single reaction catalyzed by EC 4.1.1.21 in vertebrates. -!- Carboxyphosphate is the putative acyl phosphate intermediate. -!- Involved in the late stages of purine biosynthesis.
|
UniProtKB Entries (1)
P09029 |
PURK_ECOLI
Escherichia coli K-12
N5-carboxyaminoimidazole ribonucleotide synthase
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PDB Structure
PDB | 3ETJ |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Structural analysis of the active site geometry of N(5)-Carboxyaminoimidazole ribonucleotide synthetase from Escherichia coli.
Biochemistry
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