CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.630 | Cytochrome p450 |
|
1.10.630.10 | Cytochrome P450 |
Domain Context
CATH Clusters
| Superfamily | Cytochrome P450 |
| Functional Family | Cytochrome P450 aromatase |
Enzyme Information
| 1.14.14.14 |
Aromatase.
based on mapping to UniProt P11511
(1) Testosterone + 3 [reduced NADPH--hemoprotein reductase] + 3 O(2) = 17-beta-estradiol + formate + 4 H(2)O + 3 [oxidized NADPH--hemoprotein reductase]. (2) Androst-4-ene-3,17-dione + 3 [reduced NADPH--hemoprotein reductase] + 3 O(2) = estrone + formate + 4 H(2)O + 3 [oxidized NADPH--hemoprotein reductase].
-!- The enzyme catalyzes three sequential hydroxylations of the androgens androst-4-ene-3,17-dione and testosterone, resulting in their aromatization and forming the estrogens estrone and 17-beta- estradiol, respectively.
|
UniProtKB Entries (1)
| P11511 |
CP19A_HUMAN
Homo sapiens
Aromatase
|
PDB Structure
| PDB | 3EQM |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural basis for androgen specificity and oestrogen synthesis in human aromatase.
Nature
|