CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.10 | Arc Repressor Mutant, subunit A |
|
1.10.10.2230 |
Domain Context
CATH Clusters
| Superfamily | 1.10.10.2230 |
| Functional Family | DNA (cytosine-5)-methyltransferase |
Enzyme Information
| 2.1.1.37 |
DNA (cytosine-5-)-methyltransferase.
based on mapping to UniProt P26358
S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.
-!- See the REBASE database for a complete list of these enzymes: http://rebase.neb.com/rebase/ -!- Formerly EC 2.1.1.73.
|
UniProtKB Entries (1)
| P26358 |
DNMT1_HUMAN
Homo sapiens
DNA (cytosine-5)-methyltransferase 1
|
PDB Structure
| PDB | 3EPZ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
The replication focus targeting sequence (RFTS) domain is a DNA-competitive inhibitor of Dnmt1.
J.Biol.Chem.
|
