CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.420 | Nucleotidyltransferase; domain 5 |
|
3.30.420.40 | ATPase, nucleotide binding domain |
Domain Context
CATH Clusters
| Superfamily | 3.30.420.40 |
| Functional Family | Probable tRNA N6-adenosine threonylcarbamoyltransferase |
Enzyme Information
| 2.7.11.1 |
Non-specific serine/threonine protein kinase.
based on mapping to UniProt Q9HLA5
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.
|
| 2.3.1.234 |
N(6)-L-threonylcarbamoyladenine synthase.
based on mapping to UniProt Q9HLA5
L-threonylcarbamoyladenylate + adenine(37) in tRNA = AMP + N(6)-L- threonylcarbamoyladenine(37) in tRNA.
-!- The enzyme is involved in the synthesis of N(6)- threonylcarbamoyladenosine(37) in tRNAs, which is found in tRNAs with the anticodon NNU, i.e. tRNA(Ile), tRNA(Thr), tRNA(Asn), tRNA(Lys), tRNA(Ser) and tRNA(Arg). -!- Formerly EC 2.6.99.4.
|
UniProtKB Entries (2)
| Q8TZI1 |
Q8TZI1_PYRFU
Pyrococcus furiosus DSM 3638
Uncharacterized protein
|
| Q9HLA5 |
KAE1B_THEAC
Thermoplasma acidophilum DSM 1728
Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein
|
PDB Structure
| PDB | 3ENO |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine.
Mol.Cell
|
