CATH Classification
Level | CATH Code | Description |
---|---|---|
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3 | Alpha Beta |
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3.30 | 2-Layer Sandwich |
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3.30.572 | Thymidylate Synthase; Chain A |
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3.30.572.10 | Thymidylate synthase/dCMP hydroxymethylase domain |
Domain Context
CATH Clusters
Superfamily | Thymidylate synthase/dCMP hydroxymethylase domain |
Functional Family | Possible thymidylate synthase |
Enzyme Information
2.1.1.45 |
Thymidylate synthase.
based on mapping to UniProt P04818
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.
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UniProtKB Entries (1)
P04818 |
TYSY_HUMAN
Homo sapiens
Thymidylate synthase
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PDB Structure
PDB | 3EJL |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Replacement of Val3 in human thymidylate synthase affects its kinetic properties and intracellular stability .
Biochemistry
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