CATH Domain 3egmA00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.1260	Ferritin
	1.20.1260.10	Ferritin, core subunit, four-helix bundle

Domain Context

CATH Clusters

Superfamily	1.20.1260.10
Functional Family	Non-heme ferritin

Enzyme Information

1.16.3.2

Bacterial non-heme ferritin.

based on mapping to UniProt Q9ZLI1

4 Fe(2+) + O(2) + 6 H(2)O = 4 (FeO(OH)) + 8 H(+).

-!- Ferritins are intracellular iron-storage and detoxification proteins found in all kingdoms of life. -!- They are formed from two subunits that co-assemble in various ratios to form a spherical protein shell. -!- Thousands of mineralized iron atoms are stored within the core of the structure. -!- The product of dioxygen reduction by the bacterial non-heme ferritin is hydrogen peroxide, which is consumed in a subsequent reaction.

UniProtKB Entries (1)

Q9ZLI1

FTN_HELPJ

Helicobacter pylori J99

Bacterial non-heme ferritin

PDB Structure

PDB	3EGM
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The crystal structure of ferritin from Helicobacter pylori reveals unusual conformational changes for iron uptake. Cho, K.J., Shin, H.J., Lee, J.H., Kim, K.J., Park, S.S., Lee, Y., Lee, C., Park, S.S., Kim, K.H. J.Mol.Biol.