CATH Domain 3efjA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Hepatocyte growth factor receptor

Enzyme Information

2.7.10.1

Receptor protein-tyrosine kinase.

based on mapping to UniProt P08581

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P08581

MET_HUMAN

Homo sapiens

Hepatocyte growth factor receptor

PDB Structure

PDB	3EFJ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Design, synthesis, and biological evaluation of potent c-Met inhibitors. D'Angelo, N.D., Bellon, S.F., Booker, S.K., Cheng, Y., Coxon, A., Dominguez, C., Fellows, I., Hoffman, D., Hungate, R., Kaplan-Lefko, P., Lee, M.R., Li, C., Liu, L., Rainbeau, E., Reider, P.J., Rex, K., Siegmund, A., Sun, Y., Tasker, A.S., Xi, N., Xu, S., Yang, Y., Zhang, Y., Burgess, T.L., Dussault, I., Kim, T.S. J.Med.Chem.