CATH Classification

Domain Context

CATH Clusters

Superfamily 1.20.1050.10
Functional Family Hematopoietic prostaglandin D synthase

Enzyme Information

2.5.1.18
Glutathione transferase.
based on mapping to UniProt O60760
RX + glutathione = HX + R-S-glutathione.
-!- A group of enzymes of broad specificity. -!- R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. -!- Also catalyzes the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrile, certain isomerization reactions and disulfide interchange. -!- Formerly EC 1.8.6.1, EC 2.5.1.12, EC 2.5.1.13, EC 2.5.1.14 and EC 4.4.1.7.
5.3.99.2
Prostaglandin-D synthase.
based on mapping to UniProt O60760
(5Z,13E,15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate.
-!- Brings about the opening of the epidioxy bridge.

UniProtKB Entries (1)

O60760
HPGDS_HUMAN
Homo sapiens
Hematopoietic prostaglandin D synthase

PDB Structure

PDB 3EE2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D(2) synthase
Weber, J.E., Oakley, A.J., Christ, A.N., Clark, A.G., Hayes, J.D., Hall, R., Hume, D.A., Board, P.G., Smythe, M.L., Flanagan, J.U.
Eur.J.Med.Chem.