CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.70 | Distorted Sandwich |
|
2.70.98 | Beta-galactosidase; Chain A, domain 5 |
|
2.70.98.10 |
Domain Context
CATH Clusters
| Superfamily | 2.70.98.10 |
| Functional Family |
Enzyme Information
| 3.2.1.97 |
Endo-alpha-N-acetylgalactosaminidase.
based on mapping to UniProt Q8DR60
Beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-L- serine/L-threonine-[protein] + H(2)O = beta-D-galactosyl-(1->3)-N-acetyl- alpha-D-galactosamine + L-serine/L-threonine-[protein].
-!- The enzyme catalyzes the liberation of Gal-(1->3)-beta-GalNAc alpha- linked to serine or threonine residues of mucin-type glycoproteins. -!- EngBF from Bifidobacterium longum specifically acts on core 1-type O-glycan to release the disaccharide Gal-(1->3)-beta-GalNAc. -!- The enzymes from Clostridium perfringens, Enterococcus faecalis, Propionibacterium acnes and Alcaligenes faecalis show broader specificity (e.g. release of the core 2 trisaccharide Gal-(1->3)- beta-(GlcNAc-(1->6)-beta)-GalNAc or the core 3 disaccharide GlcNAc- (1->3)-beta-GalNAc). -!- The enzyme may play an important role in the degradation and utilization of mucins having core 1 O-glycan. -!- Formerly EC 3.2.1.110.
|
UniProtKB Entries (1)
| Q8DR60 |
GH101_STRR6
Streptococcus pneumoniae R6
Endo-alpha-N-acetylgalactosaminidase
|
PDB Structure
| PDB | 3ECQ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
The structural basis for T-antigen hydrolysis by Streptococcus pneumoniae: a target for structure-based vaccine design.
J.Biol.Chem.
|
