CATH Classification
Domain Context
CATH Clusters
| Superfamily | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain |
| Functional Family | Phosphodiesterase |
Enzyme Information
| 3.1.4.53 |
3',5'-cyclic-AMP phosphodiesterase.
based on mapping to UniProt O60658
Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate.
-!- Specific for 3',5'-cAMP and does not hydrolyze other nucleoside 3',5'-cyclic phosphates such as cGMP (cf. EC 3.1.4.17 and EC 3.1.4.35). -!- It is involved in modulation of the levels of cAMP, which is a mediator in the processes of cell transformation and proliferation. -!- Formerly EC 3.1.4.n1.
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UniProtKB Entries (1)
| O60658 |
PDE8A_HUMAN
Homo sapiens
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
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PDB Structure
| PDB | 3ECM |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Kinetic and structural studies of phosphodiesterase-8A and implication on the inhibitor selectivity
Biochemistry
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