CATH Domain 3e8dA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Non-specific serine/threonine protein kinase

Enzyme Information

2.7.11.1

Non-specific serine/threonine protein kinase.

based on mapping to UniProt P31751

ATP + a protein = ADP + a phosphoprotein.

-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

P31751

AKT2_HUMAN

Homo sapiens

RAC-beta serine/threonine-protein kinase

PDB Structure

PDB	3E8D
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Aminofurazans as potent inhibitors of AKT kinase Rouse, M.B., Seefeld, M.A., Leber, J.D., McNulty, K.C., Sun, L., Miller, W.H., Zhang, S., Minthorn, E.A., Concha, N.O., Choudhry, A.E., Schaber, M.D., Heerding, D.A. Bioorg.Med.Chem.Lett.