CATH Domain 3e6uA00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.50	Alpha/alpha barrel
	1.50.10	Glycosyltransferase
	1.50.10.10

Domain Context

CATH Clusters

Superfamily	1.50.10.10
Functional Family	LanC-like protein 1

Enzyme Information

2.5.1.18

Glutathione transferase.

based on mapping to UniProt O43813

RX + glutathione = HX + R-S-glutathione.

-!- A group of enzymes of broad specificity. -!- R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. -!- Also catalyzes the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrile, certain isomerization reactions and disulfide interchange. -!- Formerly EC 1.8.6.1, EC 2.5.1.12, EC 2.5.1.13, EC 2.5.1.14 and EC 4.4.1.7.

UniProtKB Entries (1)

O43813

LANC1_HUMAN

Homo sapiens

Glutathione S-transferase LANCL1

PDB Structure

PDB	3E6U
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure of human lanthionine synthetase C-like protein 1 and its interaction with Eps8 and glutathione Zhang, W., Wang, L., Liu, Y., Xu, J., Zhu, G., Cang, H., Li, X., Bartlam, M., Hensley, K., Li, G., Rao, Z., Zhang, X.C. Genes Dev.