CATH Domain 3e3uA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.45	Peptide Deformylase
	3.90.45.10	Peptide deformylase

Domain Context

CATH Clusters

Superfamily	Peptide deformylase
Functional Family	Peptide deformylase

Enzyme Information

3.5.1.88

Peptide deformylase.

based on mapping to UniProt P9WIJ3

Formyl-L-methionyl peptide + H(2)O = formate + methionyl peptide.

-!- Requires at least a dipeptide for an efficient rate of reaction. -!- N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. -!- Differs in substrate specificity from EC 3.5.1.27 and EC 3.5.1.31.

UniProtKB Entries (1)

P9WIJ3

DEF_MYCTU

Mycobacterium tuberculosis H37Rv

Peptide deformylase

PDB Structure

PDB	3E3U
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Peptide deformylase inhibitors of Mycobacterium tuberculosis: synthesis, structural investigations, and biological results. Pichota, A., Duraiswamy, J., Yin, Z., Keller, T.H., Alam, J., Liung, S., Lee, G., Ding, M., Wang, G., Chan, W.L., Schreiber, M., Ma, I., Beer, D., Ngew, X., Mukherjee, K., Nanjundappa, M., Teo, J.W., Thayalan, P., Yap, A., Dick, T., Meng, W., Xu, M., Koehn, J., Pan, S.H., Clark, K., Xie, X., Shoen, C., Cynamon, M. Bioorg.Med.Chem.Lett.