CATH Domain 3e16B02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family	Prostasin

Enzyme Information

3.4.21.-

Serine endopeptidases.

based on mapping to UniProt Q16651

UniProtKB Entries (1)

PRSS8_HUMAN

Homo sapiens

Prostasin

PDB Structure

PDB	3E16
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of inhibitors of the channel-activating protease prostasin (CAP1/PRSS8) utilizing structure-based design. Tully, D.C., Vidal, A., Chatterjee, A.K., Williams, J.A., Roberts, M.J., Petrassi, H.M., Spraggon, G., Bursulaya, B., Pacoma, R., Shipway, A., Schumacher, A.M., Danahay, H., Harris, J.L. Bioorg.Med.Chem.Lett.