CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.20 | Up-down Bundle |
|
1.20.58 | Methane Monooxygenase Hydroxylase; Chain G, domain 1 |
|
1.20.58.480 |
Domain Context
CATH Clusters
| Superfamily | 1.20.58.480 |
| Functional Family | Tryptophan 2,3-dioxygenase |
Enzyme Information
| 1.13.11.11 |
Tryptophan 2,3-dioxygenase.
based on mapping to UniProt Q8PDA8
L-tryptophan + O(2) = N-formyl-L-kynurenine.
-!- Catalyzes, together with EC 1.13.11.52, the first and rate-limiting step in the kynurenine pathway, the major pathway of tryptophan metabolism. -!- Specific for tryptophan as substrate, but is far more active with L-tryptophan than with D-tryptophan. -!- Formerly EC 1.11.1.4 and EC 1.13.1.12.
|
UniProtKB Entries (1)
| Q8PDA8 |
T23O_XANCP
Xanthomonas campestris pv. campestris str. ATCC 33913
Tryptophan 2,3-dioxygenase
|
PDB Structure
| PDB | 3E08 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Histidine 55 of tryptophan 2,3-dioxygenase is not an active site base but regulates catalysis by controlling substrate binding
Biochemistry
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