CATH Domain 3dz3A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.60	4-Layer Sandwich
	3.60.90	S-adenosylmethionine decarboxylase
	3.60.90.10	S-adenosylmethionine decarboxylase

Domain Context

CATH Clusters

Superfamily	S-adenosylmethionine decarboxylase
Functional Family	S-adenosylmethionine decarboxylase proenzyme

Enzyme Information

4.1.1.50

Adenosylmethionine decarboxylase.

based on mapping to UniProt P17707

S-adenosyl-L-methionine = S-adenosyl 3-(methylthio)propylamine + CO(2).

UniProtKB Entries (1)

DCAM_HUMAN

Homo sapiens

S-adenosylmethionine decarboxylase proenzyme

PDB Structure

PDB	3DZ3
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	New Insights into the Design of Inhibitors of Human S-Adenosylmethionine Decarboxylase: Studies of Adenine C8 Substitution in Structural Analogues of S-Adenosylmethionine McCloskey, D.E., Bale, S., Secrist III, J.A., Tiwari, A., Moss III, T.H., Valiyaveettil, J., Brooks, W.H., Guida, W.C., Pegg, A.E., Ealick, S.E. J.Med.Chem.