CATH Classification
Level | CATH Code | Description |
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3 | Alpha Beta |
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3.40 | 3-Layer(aba) Sandwich |
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3.40.50 | Rossmann fold |
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3.40.50.1100 |
Domain Context
CATH Clusters
Superfamily | 3.40.50.1100 |
Functional Family | Cysteine synthase A |
Enzyme Information
2.5.1.113 |
[CysO sulfur-carrier protein]-thiocarboxylate-dependent cysteine synthase.
based on mapping to UniProt P9WP53
O-phospho-L-serine + [CysO sulfur-carrier protein]-Gly-NH-CH(2)-C(O)SH = [CysO sulfur-carrier protein]-Gly-NH-CH(2)-C(O)-S-L-cysteine + phosphate.
-!- The enzyme participates in an alternative pathway for L-cysteine biosynthesis that involves a protein-bound thiocarboxylate as the sulfide donor. -!- The enzyme from the bacterium Mycobacterium tuberculosis also has very low activity with O(3)-acetyl-L-serine (cf. EC 2.5.1.65). -!- Formerly EC 2.5.1.n5.
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UniProtKB Entries (1)
P9WP53 |
CYSM_MYCTU
Mycobacterium tuberculosis H37Rv
O-phosphoserine sulfhydrylase
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PDB Structure
PDB | 3DWI |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Crystal structure of a sulfur carrier protein complex found in the cysteine biosynthetic pathway of Mycobacterium tuberculosis.
Biochemistry
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