CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphoenolpyruvate Carboxykinase, domain 2
Functional Family Phosphoenolpyruvate carboxykinase, cytosolic [GTP]

Enzyme Information

4.1.1.32
Phosphoenolpyruvate carboxykinase (GTP).
based on mapping to UniProt P07379
GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO(2).
-!- ITP can act as phosphate donor.

UniProtKB Entries (1)

P07379
PCKGC_RAT
Rattus norvegicus
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]

PDB Structure

PDB 3DT4
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Enzymes with lid-gated active sites must operate by an induced fit mechanism instead of conformational selection.
Sullivan, S.M., Holyoak, T.
Proc.Natl.Acad.Sci.Usa
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