CATH Classification

Domain Context

CATH Clusters

Superfamily Ribonucleotide Reductase, subunit A
Functional Family

Enzyme Information

1.14.13.236
Toluene 4-monooxygenase.
based on mapping to UniProt Q00456
Toluene + NADH + O(2) = 4-methylphenol + NAD(+) + H(2)O.
-!- This bacterial enzyme belongs to a family of soluble diiron hydroxylases that includes toluene-, benzene-, xylene- and methane monooxygenases, phenol hydroxylases, and alkene epoxidases. -!- The enzyme comprises a four-component complex that includes a hydroxylase, NADH-ferredoxin oxidoreductase, a Rieske-type [2Fe-2S] ferredoxin, and an effector protein.

UniProtKB Entries (1)

Q00459
TMOD_PSEME
Pseudomonas mendocina
Toluene-4-monooxygenase system, effector component

PDB Structure

PDB 3DHH
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural consequences of effector protein complex formation in a diiron hydroxylase.
Bailey, L.J., McCoy, J.G., Phillips Jr., G.N., Fox, B.G.
Proc.Natl.Acad.Sci.USA