CATH Domain 3dgqA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.30	Glutaredoxin
	3.40.30.10	Glutaredoxin

Domain Context

CATH Clusters

Superfamily	Glutaredoxin
Functional Family	Glutathione S-transferase P

Enzyme Information

2.5.1.18

Glutathione transferase.

based on mapping to UniProt P09211

RX + glutathione = HX + R-S-glutathione.

-!- A group of enzymes of broad specificity. -!- R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. -!- Also catalyzes the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrile, certain isomerization reactions and disulfide interchange. -!- Formerly EC 1.8.6.1, EC 2.5.1.12, EC 2.5.1.13, EC 2.5.1.14 and EC 4.4.1.7.

UniProtKB Entries (1)

P09211

GSTP1_HUMAN

Homo sapiens

Glutathione S-transferase P

PDB Structure

PDB	3DGQ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Rational design of an organometallic glutathione transferase inhibitor Ang, W.H., Parker, L.J., De Luca, A., Juillerat-Jeanneret, L., Morton, C.J., Lo Bello, M., Parker, M.W., Dyson, P.J. Angew.Chem.Int.Ed.Engl.