CATH Domain 3ddgA05

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.40	Immunoglobulin-like
	2.60.40.1360

Domain Context

CATH Clusters

Superfamily	2.60.40.1360
Functional Family	Alpha-mannosidase 2

Enzyme Information

3.2.1.114

Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase.

based on mapping to UniProt Q24451

Man(5)GlcNAc(3)-[protein] + 2 H(2)O = Man(3)GlcNAc(3)-[protein] + 2 alpha-D-mannopyranose.

-!- The enzyme, found in plants and animals, participates in the processing of N-glycans in the Golgi apparatus. -!- It removes two mannosyl residues, one linked by alpha-1,3 linkage, and the other linked by alpha-1,6 linkage, both of which are removed by the same catalytic site. -!- The enzyme is sensitive to swainsonine.

UniProtKB Entries (1)

Q24451

MAN2_DROME

Drosophila melanogaster

Alpha-mannosidase 2

PDB Structure

PDB	3DDG
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Functionalized pyrrolidine inhibitors of human type II alpha-mannosidases as anti-cancer agents: optimizing the fit to the active site Fiaux, H., Kuntz, D.A., Hoffman, D., Janzer, R.C., Gerber-Lemaire, S., Rose, D.R., Juillerat-Jeanneret, L. Bioorg.Med.Chem.