CATH Classification
Level | CATH Code | Description |
---|---|---|
2 | Mainly Beta | |
2.60 | Sandwich | |
2.60.40 | Immunoglobulin-like | |
2.60.40.1360 |
Domain Context
CATH Clusters
Superfamily | 2.60.40.1360 |
Functional Family | Alpha-mannosidase 2 |
Enzyme Information
3.2.1.114 |
Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase.
based on mapping to UniProt Q24451
Man(5)GlcNAc(3)-[protein] + 2 H(2)O = Man(3)GlcNAc(3)-[protein] + 2 alpha-D-mannopyranose.
-!- The enzyme, found in plants and animals, participates in the processing of N-glycans in the Golgi apparatus. -!- It removes two mannosyl residues, one linked by alpha-1,3 linkage, and the other linked by alpha-1,6 linkage, both of which are removed by the same catalytic site. -!- The enzyme is sensitive to swainsonine.
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UniProtKB Entries (1)
Q24451 |
MAN2_DROME
Drosophila melanogaster
Alpha-mannosidase 2
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PDB Structure
PDB | 3DDG |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Functionalized pyrrolidine inhibitors of human type II alpha-mannosidases as anti-cancer agents: optimizing the fit to the active site
Bioorg.Med.Chem.
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