CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.70 | Distorted Sandwich |
|
2.70.98 | Beta-galactosidase; Chain A, domain 5 |
|
2.70.98.30 | Golgi alpha-mannosidase II; domain 4 |
Domain Context
CATH Clusters
| Superfamily | Golgi alpha-mannosidase II; domain 4 |
| Functional Family | Alpha-mannosidase |
Enzyme Information
| 3.2.1.114 |
Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase.
based on mapping to UniProt Q24451
Man(5)GlcNAc(3)-[protein] + 2 H(2)O = Man(3)GlcNAc(3)-[protein] + 2 alpha-D-mannopyranose.
-!- The enzyme, found in plants and animals, participates in the processing of N-glycans in the Golgi apparatus. -!- It removes two mannosyl residues, one linked by alpha-1,3 linkage, and the other linked by alpha-1,6 linkage, both of which are removed by the same catalytic site. -!- The enzyme is sensitive to swainsonine.
|
UniProtKB Entries (1)
| Q24451 |
MAN2_DROME
Drosophila melanogaster
Alpha-mannosidase 2
|
PDB Structure
| PDB | 3DDG |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Functionalized pyrrolidine inhibitors of human type II alpha-mannosidases as anti-cancer agents: optimizing the fit to the active site
Bioorg.Med.Chem.
|