CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.90 | Alpha-Beta Complex |
|
3.90.1240 | Zincin-like |
|
3.90.1240.10 | Metalloproteases ("zincins"), catalytic domain like |
Domain Context
CATH Clusters
| Superfamily | Metalloproteases ("zincins"), catalytic domain like |
| Functional Family | Botulinum neurotoxin type A |
Enzyme Information
| 3.4.24.69 |
Bontoxilysin.
based on mapping to UniProt P0DPI1
Limited hydrolysis of proteins of the neuroexocytosis apparatus, synaptobrevins, SNAP25 or syntaxin. No detected action on small molecule substrates.
-!- Belongs to peptidase family M27.
|
UniProtKB Entries (2)
| P0DPI1 |
BXA1_CLOBH
Clostridium botulinum A str. Hall
Botulinum neurotoxin type A
|
| P60880 |
SNP25_HUMAN
Homo sapiens
Synaptosomal-associated protein 25
|
PDB Structure
| PDB | 3DDB |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Substrate binding mode and its implication on drug design for botulinum neurotoxin A
Plos Pathog.
|
