CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.100 | NADP-dependent oxidoreductase domain |
Domain Context
CATH Clusters
| Superfamily | NADP-dependent oxidoreductase domain |
| Functional Family | Oxidoreductase, aldo/keto reductase family |
Enzyme Information
| 1.1.1.- |
With NAD(+) or NADP(+) as acceptor.
based on mapping to UniProt O32210
|
| 1.1.1.283 |
Methylglyoxal reductase (NADPH).
based on mapping to UniProt O32210
(S)-lactaldehyde + NADP(+) = 2-oxopropanal + NADPH.
-!- The enzyme from the yeast Saccharomyces cerevisiae catalyzes the reduction of a keto group in a number of compounds, forming enantiopure products. -!- Among the substrates are methylglyoxal (which is reduced to (S)- lactaldehyde), 3-methylbutanal, hexane-2,5-dione and 3-chloro-1- phenylpropan-1-one. -!- The enzyme differs from EC 1.1.1.78 which is found in mammals, by its coenzyme requirement, reaction direction, and enantiomeric preference.
|
UniProtKB Entries (1)
| O32210 |
GR_BACSU
Bacillus subtilis subsp. subtilis str. 168
Glyoxal reductase
|
PDB Structure
| PDB | 3D3F |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural and biochemical analyses of YvgN and YtbE from Bacillus subtilis
Protein Sci.
|
