CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Corticosteroid 11-beta-dehydrogenase isozyme 1

Enzyme Information

1.1.1.146
11-beta-hydroxysteroid dehydrogenase.
based on mapping to UniProt P28845
An 11-beta-hydroxysteroid + NADP(+) = an 11-oxosteroid + NADPH.

UniProtKB Entries (1)

P28845
DHI1_HUMAN
Homo sapiens
Corticosteroid 11-beta-dehydrogenase isozyme 1

PDB Structure

PDB 3D3E
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of Novel, Potent Benzamide Inhibitors of 11beta-Hydroxysteroid Dehydrogenase Type 1 (11beta-HSD1) Exhibiting Oral Activity in an Enzyme Inhibition ex Vivo Model
Julian, L.D., Wang, Z., Bostick, T., Caille, S., Choi, R., Degraffenreid, M., Di, Y., He, X., Hungate, R.W., Jaen, J.C., Liu, J., Monshouwer, M., McMinn, D., Rew, Y., Sudom, A., Sun, D., Tu, H., Ursu, S., Walker, N., Yan, X., Ye, Q., Powers, J.P.
J.Med.Chem.