CATH Domain 3d15A02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Aurora kinase A

Enzyme Information

2.7.11.1

Non-specific serine/threonine protein kinase.

based on mapping to UniProt P97477

ATP + a protein = ADP + a phosphoprotein.

-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

P97477

AURKA_MOUSE

Mus musculus

Aurora kinase A

PDB Structure

PDB	3D15
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of a potent and selective aurora kinase inhibitor. Oslob, J.D., Romanowski, M.J., Allen, D.A., Baskaran, S., Bui, M., Elling, R.A., Flanagan, W.M., Fung, A.D., Hanan, E.J., Harris, S., Heumann, S.A., Hoch, U., Jacobs, J.W., Lam, J., Lawrence, C.E., McDowell, R.S., Nannini, M.A., Shen, W., Silverman, J.A., Sopko, M.M., Tangonan, B.T., Teague, J., Yoburn, J.C., Yu, C.H., Zhong, M., Zimmerman, K.M., O'Brien, T., Lew, W. Bioorg.Med.Chem.Lett.