CATH Domain 3cxvA00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.630	Cytochrome p450
	1.10.630.10	Cytochrome P450

Domain Context

CATH Clusters

Superfamily	Cytochrome P450
Functional Family	Mycocyclosin synthase

Enzyme Information

1.14.-.-

Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O(2).

based on mapping to UniProt P9WPP7

1.14.19.70

Mycocyclosin synthase.

based on mapping to UniProt P9WPP7

Cyclo(L-tyrosyl-L-tyrosyl) + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H(+) + O(2) = mycocyclosin + 2 oxidized ferredoxin [iron-sulfur] cluster + 2 H(2)O.

-!- A cytochrome P450 (heme-thiolate) protein from the bacterium Mycobacterium tuberculosis catalyzing an oxidative reaction that does not incorporate oxygen into the product. -!- Formerly EC 1.14.21.9.

UniProtKB Entries (1)

P9WPP7

CP121_MYCTU

Mycobacterium tuberculosis H37Rv

Mycocyclosin synthase

PDB Structure

PDB	3CXV
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Characterization of active site structure in CYP121. A cytochrome P450 essential for viability of Mycobacterium tuberculosis H37Rv. McLean, K.J., Carroll, P., Lewis, D.G., Dunford, A.J., Seward, H.E., Neeli, R., Cheesman, M.R., Marsollier, L., Douglas, P., Smith, W.E., Rosenkrands, I., Cole, S.T., Leys, D., Parish, T., Munro, A.W. J.Biol.Chem.