CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.630 | Cytochrome p450 |
|
1.10.630.10 | Cytochrome P450 |
Domain Context
CATH Clusters
| Superfamily | Cytochrome P450 |
| Functional Family | Cytochrome P450 monooxygenase |
Enzyme Information
| 1.14.15.22 |
Vitamin D 1,25-hydroxylase.
based on mapping to UniProt P18326
(1) Calciol + O(2) + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H(+) = calcidiol + 2 oxidized ferredoxin [iron-sulfur] cluster + H(2)O. (2) Calcidiol + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H(+) + O(2) = calcitriol + 2 oxidized ferredoxin [iron-sulfur] cluster + H(2)O.
-!- An enzyme found in the bacterium Streptomyces griseolus. -!- Cf. EC 1.14.14.24 and EC 1.14.15.18.
|
UniProtKB Entries (1)
| P18326 |
CPXE_STRGO
Streptomyces griseolus
Vitamin D3 dihydroxylase
|
PDB Structure
| PDB | 3CV8 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure-based design of a highly active vitamin D hydroxylase from Streptomyces griseolus CYP105A1
Biochemistry
|
