CATH Domain 3cpcA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Vascular endothelial growth factor receptor 2

Enzyme Information

2.7.10.1

Receptor protein-tyrosine kinase.

based on mapping to UniProt P35968

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P35968

VGFR2_HUMAN

Homo sapiens

Vascular endothelial growth factor receptor 2

PDB Structure

PDB	3CPC
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of Aryl Aminoquinazoline Pyridones as Potent, Selective, and Orally Efficacious Inhibitors of Receptor Tyrosine Kinase c-Kit. Hu, E., Tasker, A., White, R.D., Kunz, R.K., Human, J., Chen, N., Burli, R., Hungate, R., Novak, P., Itano, A., Zhang, X., Yu, V., Nguyen, Y., Tudor, Y., Plant, M., Flynn, S., Xu, Y., Meagher, K.L., Whittington, D.A., Ng, G.Y. J.Med.Chem.