CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.20 | Alpha-Beta Barrel | |
3.20.20 | TIM Barrel | |
3.20.20.100 | NADP-dependent oxidoreductase domain |
Domain Context
CATH Clusters
Superfamily | NADP-dependent oxidoreductase domain |
Functional Family | Aldo-keto reductase family 1 member C3 |
Enzyme Information
1.3.1.3 |
Delta(4)-3-oxosteroid 5-beta-reductase.
based on mapping to UniProt P51857
(1) 5-beta-cholestan-3-one + NADP(+) = cholest-4-en-3-one + NADPH. (2) 17,21-dihydroxy-5-beta-pregnane-3,11,20-trione + NADP(+) = cortisone + NADPH.
-!- The enzyme from human efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites; it can also act on aldosterone, corticosterone and cortisol, but to a lesser extent. -!- The bile acid intermediates 7-alpha,12-alpha-dihydroxy-4-cholesten-3- one and 7-alpha-hydroxy-4-cholesten-3-one can also act as substrates.
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UniProtKB Entries (1)
P51857 |
AK1D1_HUMAN
Homo sapiens
3-oxo-5-beta-steroid 4-dehydrogenase
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PDB Structure
PDB | 3COT |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
Crystal Structure of Human Liver {Delta}4-3-Ketosteroid 5{beta}-Reductase (AKR1D1) and Implications for Substrate Binding and Catalysis.
J.Biol.Chem.
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