CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.1060 | Fumarate Reductase Iron-sulfur Protein; Chain B, domain 2 |
|
1.10.1060.10 | Alpha-helical ferredoxin |
Domain Context
CATH Clusters
| Superfamily | Alpha-helical ferredoxin |
| Functional Family | Succinate dehydrogenase iron-sulfur subunit |
Enzyme Information
| 1.3.5.1 |
Succinate dehydrogenase (quinone).
based on mapping to UniProt P0AC47
Succinate + a quinone = fumarate + a quinol.
-!- The enzyme is found in the inner mitochondrial membrane in eukaryotes and the plasma membrane of many aerobic or facultative bacteria. -!- It catalyzes succinate oxidation in the citric acid cycle and transfers the electrons to quinones in the membrane, thus constituting a part of the aerobic respiratory chain (known as complex II). -!- In vivo the enzyme uses the quinone found in the organism - eukaryotic enzymes utilize ubiquinone, bacterial enzymes utilize ubiquinone or menaquinone, and archaebacterial enzymes from the Sulfolobus genus use caldariellaquinone. -!- Cf. EC 1.3.5.4.
|
UniProtKB Entries (1)
| P00363 |
FRDA_ECOLI
Escherichia coli K-12
Fumarate reductase flavoprotein subunit
|
PDB Structure
| PDB | 3CIR |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
A threonine on the active site loop controls transition state formation in Escherichia coli respiratory complex II.
J.Biol.Chem.
|
