CATH Domain 3cenA01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family	Coagulation factor X

Enzyme Information

3.4.21.6

Coagulation factor Xa.

based on mapping to UniProt P00742

Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin.

-!- A blood coagulation factor formed from the proenzyme factor X by limited proteolysis. -!- Factor X is a glycoprotein composed of a heavy chain and a light chain, which are generated from a precursor protein by the excision of the tripeptide RKR and held together by one or more disulfide bonds. -!- The activated factor Xa converts prothrombin to thrombin in the presence of factor Va, Ca(2+) and phospholipids. -!- Scutelarin (EC 3.4.21.60) has similar specificity, but does not require factor Va. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P00742

FA10_HUMAN

Homo sapiens

Coagulation factor X

PDB Structure

PDB	3CEN
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure-Activity Relationships of Anthranilamide-Based Factor Xa Inhibitors Containing Piperidinone and Pyridinone P4 Moieties Corte, J.R., Fang, T., Pinto, D.J.P., Han, W., Hu, Z., Jiang, X.-J., Li, Y.-L., Gauuan, J.F., Hadden, M., Orton, D., Rendina, A.R., Luettgen, J.M., Wong, P.C., He, K., Morin, P., Chang, C.-H., Cheney, D.L., Knabb, R.M., Wexler, R.R., Lam, P.Y.S. Bioorg.Med.Chem.Lett.