CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.30 | 2-Layer Sandwich | |
3.30.70 | Alpha-Beta Plaits | |
3.30.70.270 | Reverse transcriptase/Diguanylate cyclase domain |
Domain Context
CATH Clusters
Superfamily | 3.30.70.270 |
Functional Family |
Enzyme Information
3.6.1.15 |
Nucleoside-triphosphate phosphatase.
based on mapping to UniProt P03313
NTP + H(2)O = NDP + phosphate.
-!- The enzyme is found in eukaryotes and thermophilic bacteria, but appears to be absent from mesophilic bacteria. -!- Also hydrolyzes nucleoside diphosphates, thiamine diphosphate and FAD. -!- The enzyme from the plant Pisum sativum (garden pea) is regulated by calmodulin.
|
2.7.7.48 |
RNA-directed RNA polymerase.
based on mapping to UniProt P03313
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- See also EC 2.7.7.6.
|
3.4.22.28 |
Picornain 3C.
based on mapping to UniProt P03313
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
-!- From entero-, rhino-, aphto- and cardioviruses. -!- Larger than the homologous virus picornain 2A. -!- Belongs to peptidase family C3.
|
3.4.22.29 |
Picornain 2A.
based on mapping to UniProt P03313
Selective cleavage of Tyr-|-Gly bond in the picornavirus polyprotein.
-!- From entero- and rhinoviruses. -!- Smaller than the homologous virus picornain 3C. -!- Belongs to peptidase family C3.
|
UniProtKB Entries (1)
P03313 |
POLG_CXB3N
Coxsackievirus B3 (strain Nancy)
Genome polyprotein
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PDB Structure
PDB | 3CDU |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
The crystal structure of coxsackievirus B3 RNA-dependent RNA polymerase in complex with its protein primer VPg confirms the existence of a second VPg binding site on Picornaviridae polymerases
J.Virol.
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