1 keywords

CATH Domain 3ccwC02

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.90 Alpha-Beta Complex
Topology 3.90.770 3-hydroxy-3-methylglutaryl-coenzyme A Reductase; Chain A, domain 2
Homologous Superfamily 3.90.770.10 3-hydroxy-3-methylglutaryl-coenzyme A Reductase; Chain A, domain 2

Domain Context

CATH Clusters

Superfamily 3-hydroxy-3-methylglutaryl-coenzyme A Reductase; Chain A, domain 2
Functional Family 3-hydroxy-3-methylglutaryl coenzyme A reductase

Enzyme Information

1.1.1.34
Hydroxymethylglutaryl-CoA reductase (NADPH).
based on mapping to UniProt P04035
(R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH.
-!- The enzyme is inactivated by EC 2.7.11.31 and reactivated by EC 3.1.3.47.

UniProtKB Entries (1)

P04035
HMDH_HUMAN
Homo sapiens
3-hydroxy-3-methylglutaryl-coenzyme A reductase

PDB Structure

PDB 3CCW
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Thermodynamic and structure guided design of statin based inhibitors of 3-hydroxy-3-methylglutaryl coenzyme a reductase.
Sarver, R.W., Bills, E., Bolton, G., Bratton, L.D., Caspers, N.L., Dunbar, J.B., Harris, M.S., Hutchings, R.H., Kennedy, R.M., Larsen, S.D., Pavlovsky, A., Pfefferkorn, J.A., Bainbridge, G.
J.Med.Chem.