CATH Classification
Domain Context
CATH Clusters
| Superfamily | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases |
| Functional Family |
Enzyme Information
| 6.3.1.13 |
L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase.
based on mapping to UniProt A0QZY0
1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + L-cysteine + ATP = 1-O-(2-(L-cysteinamido)-2-deoxy-alpha-D-glucopyranosyl)-1D-myo- inositol + AMP + diphosphate.
-!- This enzyme is a key enzyme in the biosynthesis of mycothiol, a small molecular weight thiol found in Mycobacteria spp. and other actinomycetes. -!- Mycothiol plays a fundamental role in these organisms by helping to provide protection from the effects of reactive oxygen species and electrophiles, including many antibiotics. -!- The enzyme may represent a novel target for new classes of antituberculars. -!- Formerly EC 6.1.1.n1.
|
UniProtKB Entries (1)
| A0QZY0 |
MSHC_MYCS2
Mycolicibacterium smegmatis MC2 155
L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase
|
PDB Structure
| PDB | 3C8Z |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
The 1.6 A crystal structure of Mycobacterium smegmatis MshC: the penultimate enzyme in the mycothiol biosynthetic pathway.
Biochemistry
|
