CATH Domain 3c7xA00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.110	4 Propeller
	2.110.10	Hemopexin
	2.110.10.10	Hemopexin-like domain

Domain Context

CATH Clusters

Superfamily	Hemopexin-like domain
Functional Family	Matrix metallopeptidase 24

Enzyme Information

3.4.24.80

Membrane-type matrix metalloproteinase-1.

based on mapping to UniProt P50281

Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at 37-Asn-|-Leu-38. Other bonds hydrolyzed include 35-Gly-|-Ile-36 in the propeptide of collagenase 3, and 341-Asn-|-Phe- 342, 441-Asp-|-Leu-442 and 354-Gln-|-Thr-355 in the aggrecan interglobular domain.

-!- Believed to play an important role in the activation of progelatinase A at cell surfaces. -!- Belongs to peptidase family M10.

UniProtKB Entries (1)

P50281

MMP14_HUMAN

Homo sapiens

Matrix metalloproteinase-14

PDB Structure

PDB	3C7X
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The dimer interface of the membrane type 1 matrix metalloproteinase hemopexin domain: crystal structure and biological functions Tochowicz, A., Goettig, P., Evans, R., Visse, R., Shitomi, Y., Palmisano, R., Ito, N., Richter, K., Maskos, K., Franke, D., Svergun, D., Nagase, H., Bode, W., Itoh, Y. J.Biol.Chem.