CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.2000 | Glycogen Phosphorylase B; |
Domain Context
CATH Clusters
| Superfamily | Glycogen Phosphorylase B; |
| Functional Family |
Enzyme Information
| 2.4.1.250 |
D-inositol-3-phosphate glycosyltransferase.
based on mapping to UniProt Q8NTA6
UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate = UDP + 1-O- (2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate.
-!- The enzyme, which belongs to the GT-B fold superfamily, catalyzes the first dedicated reaction in the biosynthesis of mycothiol. -!- The substrate was initially believed to be inositol, but eventually shown to be D-myo-inositol 3-phosphate. -!- A substantial conformational change occurs upon UDP binding, which generates the binding site for D-myo-inositol 3-phosphate. -!- Formerly EC 2.4.1.n3.
|
UniProtKB Entries (1)
| Q8NTA6 |
MSHA_CORGL
Corynebacterium glutamicum ATCC 13032
D-inositol 3-phosphate glycosyltransferase
|
PDB Structure
| PDB | 3C48 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structural and Enzymatic Analysis of MshA from Corynebacterium glutamicum: SUBSTRATE-ASSISTED CATALYSIS
J.Biol.Chem.
|
