CATH Domain 3c1kA01

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Superfamily	Trypsin-like serine proteases
Functional Family	Prothrombin

3.4.21.5

Thrombin.

based on mapping to UniProt P00734

Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.

-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.

P00734	THRB_HUMAN Homo sapiens Prothrombin
P28511	HIR3C_HIRME Hirudo medicinalis Hirudin-3B'

PDB	3C1K
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure-based design of novel groups for use in the P1 position of thrombin inhibitor scaffolds. Part 2: N-acetamidoimidazoles. Isaacs, R.C., Solinsky, M.G., Cutrona, K.J., Newton, C.L., Naylor-Olsen, A.M., McMasters, D.R., Krueger, J.A., Lewis, S.D., Lucas, B.J., Kuo, L.C., Yan, Y., Lynch, J.J., Lyle, E.A. Bioorg.Med.Chem.Lett.