CATH Domain 3c10A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.800	Arginase; Chain A
	3.40.800.20	Histone deacetylase domain

Domain Context

CATH Clusters

Superfamily	Histone deacetylase domain
Functional Family	Histone deacetylase

Enzyme Information

3.5.1.98

Histone deacetylase.

based on mapping to UniProt Q8WUI4

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

-!- A class of enzymes that remove acetyl groups from N(6)-acetyl-lysine residues on a histone. -!- The reaction of this enzyme is opposite to that of EC 2.3.1.48. -!- Histone deacetylases (HDACs) can be organized into three classes depending on sequence similarity and domain organization. -!- Histone acetylation plays an important role in regulation of gene expression. -!- In eukaryotes, HDACs play a key role in the regulation of transcription and cell proliferation. -!- May be identical to EC 3.5.1.17.

UniProtKB Entries (1)

Q8WUI4

HDAC7_HUMAN

Homo sapiens

Histone deacetylase 7

PDB Structure

PDB	3C10
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity. Schuetz, A., Min, J., Allali-Hassani, A., Schapira, M., Shuen, M., Loppnau, P., Mazitschek, R., Kwiatkowski, N.P., Lewis, T.A., Maglathin, R.L., McLean, T.H., Bochkarev, A., Plotnikov, A.N., Vedadi, M., Arrowsmith, C.H. J.Biol.Chem.