CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.200 | Phosphorylase Kinase; domain 1 |
|
3.30.200.20 | Phosphorylase Kinase; domain 1 |
Domain Context
CATH Clusters
| Superfamily | Phosphorylase Kinase; domain 1 |
| Functional Family | focal adhesion kinase 1 isoform X2 |
Enzyme Information
| 2.7.10.2 |
Non-specific protein-tyrosine kinase.
based on mapping to UniProt Q05397
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.
|
UniProtKB Entries (1)
| Q05397 |
FAK1_HUMAN
Homo sapiens
Focal adhesion kinase 1
|
PDB Structure
| PDB | 3BZ3 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Spodoptera |
| Primary Citation |
Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271.
Cancer Res.
|
