CATH Domain 3bv9B01

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Superfamily	Trypsin-like serine proteases
Functional Family	Prothrombin

3.4.21.5

Thrombin.

based on mapping to UniProt P00734

Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.

-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.

THRB_HUMAN

Homo sapiens

Prothrombin

PDB	3BV9
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Cricetulus
Primary Citation	Thrombostatin FM compounds: direct thrombin inhibitors - mechanism of action in vitro and in vivo. Nieman, M.T., Burke, F., Warnock, M., Zhou, Y., Sweigart, J., Chen, A., Ricketts, D., Lucchesi, B.R., Chen, Z., Di Cera, E., Hilfinger, J., Kim, J.S., Mosberg, H.I., Schmaier, A.H. J.Thromb.Haemost.