CATH Domain 3bl9A02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.428	HIT family, subunit A
	3.30.428.10	HIT-like

Domain Context

CATH Clusters

Superfamily	HIT-like
Functional Family	m7GpppX diphosphatase

Enzyme Information

3.6.1.59

5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase.

based on mapping to UniProt Q96C86

A 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] + H(2)O = N(7)- methylguanosine 5'-phosphate + a 5'-diphospho-[mRNA].

-!- The enzyme removes (decaps) the N(7)-methylguanosine 5-phosphate cap from an mRNA degraded to a maximal length of 10 nucleotides. -!- Decapping is an important process in the control of eukaryotic mRNA degradation. -!- The enzyme functions to clear the cell of cap structure following decay of the RNA body. -!- The nematode enzyme can also decap triply methylated substrates, 5'-(N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-[mRNA]. -!- Formerly EC 3.6.1.30.

UniProtKB Entries (1)

Q96C86

DCPS_HUMAN

Homo sapiens

M7GpppX diphosphatase

PDB Structure

PDB	3BL9
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	DcpS as a therapeutic target for spinal muscular atrophy. Singh, J., Salcius, M., Liu, S.W., Staker, B.L., Mishra, R., Thurmond, J., Michaud, G., Mattoon, D.R., Printen, J., Christensen, J., Bjornsson, J.M., Pollok, B.A., Kiledjian, M., Stewart, L., Jarecki, J., Gurney, M.E. Acs Chem.Biol.