CATH Domain 3bjcA00

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.1300	Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b
	1.10.1300.10	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

Superfamily	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Functional Family	Phosphodiesterase

3.1.4.35

3',5'-cyclic-GMP phosphodiesterase.

based on mapping to UniProt O76074

Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.

PDE5A_HUMAN

Homo sapiens

CGMP-specific 3',5'-cyclic phosphodiesterase

PDB	3BJC
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	An insight into the pharmacophores of phosphodiesterase-5 inhibitors from synthetic and crystal structural studies Chen, G., Wang, H., Robinson, H., Cai, J., Wan, Y., Ke, H. BIOCHEM.PHARM.